What to know about hantavirus, the illness linked to deadly cruise ship outbreak | List of symptoms

HOUSTON — Hantavirus pulmonary syndrome (HPS) has been in the news because of the three deaths aboard a ship in the Atlantic off the coast of South Africa.  We’ve now learned two people who were aboard are from Texas.

Below is information from the Centers for Disease Control and Prevention and the Associated Press on what to know about the condition, including specific symptoms.  

According to the CDC, it’s a severe and potentially deadly disease that affects the lungs. Symptoms begin to start one to eight weeks after contact with an infected rodent. 

Early symptoms can include:

• fatigue
• fever
• muscle aches, especially in the large muscle groups like the thighs, hips, back, and sometimes shoulders

The CDC says about half of the HPS patients also experience:

• headaches
• dizziness
• chills
• abdominal problems, like nausea, vomiting, diarrhea, and abdominal pain

Four to 10 days after the initial phase of HPS, the late symptoms appear. These symptoms include coughing and shortness of breath. Patients might experience chest tightness, as the lungs fill with fluid.

The CDC says 38% percent of people who develop respiratory symptoms may die from the disease.

According to the CDC, diagnosing hantavirus in a person who has been infected less than 72 hours is difficult. If the initial test is done before the virus can be found, repeat testing is often done 72 hours after symptom start. Some of the early symptoms, like fever, headache muscle aches, nausea, and fatigue are easily confused with influenza.

If you suspect hantavirus disease, you should seek medical attention immediately. and mention possible rodent exposure.

An outbreak aboard a cruise ship of a rare rodent-borne illness called hantavirus has left three passengers dead and sickened others, but global health officials say the risk to the general public remains low because the germ does not easily spread between people.

“This is not the next COVID, but it is a serious infectious disease,” said Maria Van Kerkhove, director of epidemic and pandemic preparedness at the World Health Organization. “Most people will never be exposed to this.”

The virus usually spreads when people inhale contaminated residue of rodent droppings. Hantaviruses have been around for centuries and are thought to exist around the world.

The disease gained renewed attention last year after the late actor Gene Hackman ’s wife, Betsy Arakawa, died from a hantavirus infection in New Mexico.

Detailed investigations of the cruise ship outbreak are ongoing, notably to determine its source.

Investigators in Argentina suspect that the cases were initially contracted during a birdwatching trip in Ushuaia, at the country’s southern tip, two officials told AP.

Argentina has seen a surge of hantavirus cases that many local public health researchers attribute to climate change.

Officials have found evidence of Andes virus, a version of hantavirus found in South America.

Hantavirus is mainly spread by contact with rodents or their urine, saliva or droppings, particularly when the material is disturbed and becomes airborne, posing a risk of inhalation.

People are typically exposed to hantavirus around their homes, cabins or sheds, especially when cleaning enclosed spaces with little ventilation or exploring areas with mouse droppings.

Scientists are still trying to learn exactly how the Andes virus may be able to spread between people, said Dr. Jeanne Marrazzo, chief executive officer of the Infectious Diseases Society of America. They suspect people could be infectious when they have symptoms, and, if the virus spreads, it may be transmitted through small liquid particles that blow out of an infected person when they talk, cough or sneeze.

An infection can rapidly progress and become life-threatening. Experts say it can start with symptoms including fever, chills, muscle aches and maybe a headache — much like the flu.

Symptoms of hantavirus pulmonary syndrome usually show between one and eight weeks after contact with an infected rodent. As the infection progresses, patients might experience tightness in the chest, as the lungs fill with fluid.

The other syndrome caused by hantavirus — known as hemorrhagic fever with renal syndrome, which can cause bleeding, high fever, and kidney failure — usually develops within a week or two after exposure.

Death rates vary by which hantavirus causes the illness. Hantavirus pulmonary syndrome is fatal in about 35% of people infected, while the death rate for hemorrhagic fever with renal syndrome varies from 1% to 15% of patients, according to the CDC.

Hantavirus infections are relatively uncommon globally. The WHO reported that in 2025, eight countries within the Americas had documented 229 cases and 59 deaths.

Argentina’s health ministry said hantavirus led to 28 deaths nationwide last year. The ministry on Tuesday reported 101 hantavirus infections since June 2025, roughly double the caseload recorded over the same period the previous year.

In the U.S., federal health officials began tracking the virus after a 1993 outbreak in the Four Corners region — the area where Arizona, Colorado, New Mexico and Utah meet. It was an astute physician with the Indian Health Service who first noticed a pattern of deaths among young patients.

Most U.S. cases are in Western states. New Mexico and Arizona are hot spots, likely because the odds are greater for mouse-human encounters in rural areas.

The word hantavirus refers to a broad family of viruses, with different versions in different countries. Almost none of them have been found to spread from person to person — with the possible exception of the Andes virus, which has been confirmed in the current outbreak.

Still, transmission between people does not happen easily, and would require “close and prolonged” contact, according to the WHO.

“We haven’t had huge person-to-person spreads of hantavirus infection ever before, and there’s no reason to suspect a huge outbreak from this case at this point,” said Steven Bradfute, an associate professor and associate director of the Center for Global Health at the University of New Mexico Health Sciences Center, which specializes in hantavirus research.

There is no specific treatment or cure, but early medical attention can increase the chance of survival.

Despite years of research, many questions have yet to be answered, including why it can be mild for some people and severe for others and how antibodies are developed. Some researchers have been following patients over long periods of time in hopes of finding a treatment.

“In the Americas, hantavirus infection is very serious, but it’s also quite rare,” Bradfute said. “And so for a time that probably led to less research into it because of funding priorities, but I know there’s been a lot of interest in funding hantavirus work of late.”

What researchers do know is that rodent exposure is key.

The best way to avoid the germ is to minimize contact with rodents and their droppings. Use protective gloves and a bleach solution for cleaning up rodent droppings. Public health experts caution against sweeping or vacuuming, which can cause virus particles to get into the air.

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